Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release

Nature volume 360, pages 76–78 (1992)Cite this article

Abstract

THE temporal and spatial distribution of increases in intracellular Ca2+ concentration is an important factor in cellular signal transdaction1. Inositol 1,4,5-trisphosphate (InsP3) plays a key part in agonist-induced Ca2+ release1, which can take place abruptly2 and in a confined space3 by a mechanism that is not fully understood. Here we analyse the kinetics of InsP3-induced Ca2+ release following flash photolysis4–7 of caged InsP3 or caged Ca2+, and demonstrate that Ca2+-dependent immediate feedback control is an important determinant of the time course of Ca2+ release. The positive feedback mechanism is also important for the 'loading dependence' of InsP3-induced Ca22+ release8. Furthermore, our results support the operation of positive cooperativity in channel opening9 and feedback control augments the steep InsP3 concentration-Ca2+ release relation. These inherent properties of InsP3-induced Ca2+ release are expected to give rise to temporally abrupt and/or spatially confined Ca2+ release within the cell.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Berridge, M. J. & Irvine, R. F. Nature 341, 197–205 (1989).

    Article  ADS  CAS  Google Scholar 

  2. Miyazaki, S. J. Cell Biol. 106, 345–353 (1988).

    Article  CAS  Google Scholar 

  3. Parker, I. & Ivorra, I. Science 250, 977–979 (1990).

    Article  ADS  CAS  Google Scholar 

  4. McCray, J. A. & Trentham, D. R. A. Rev. Biophys. biophys. Chem. 18, 239–270 (1989).

    Article  CAS  Google Scholar 

  5. Somlyo, A. P. & Somlyo, A. V. A. Rev. Physiol 52, 857–874 (1990).

    Article  CAS  Google Scholar 

  6. Blatt, M. R., Thiel, G. & Trentham, D. R. Nature 346, 766–769 (1990).

    Article  ADS  CAS  Google Scholar 

  7. Kaplan, J. A. A. Rev. Physiol. 52, 897–914 (1990).

    Article  CAS  Google Scholar 

  8. Missiaen, L., Taylor, C. W. & Berridge, M. J. Nature 352, 241–244 (1991).

    Article  ADS  CAS  Google Scholar 

  9. Meyer, T., Holowka, D. & Stryer, L. Science 240, 653–656 (1988).

    Article  ADS  CAS  Google Scholar 

  10. Minta, A., Kao, J. P. Y. & Tsien, R. Y. J. biol. Chem. 264, 8171–8178 (1989).

    CAS  Google Scholar 

  11. Iino, M. J. gen. Physiol. 98, 681–698 (1991).

    Article  CAS  Google Scholar 

  12. Iino, M. J. gen. Physiol. 95, 1103–1122 (1990).

    Article  CAS  Google Scholar 

  13. Bezprozvanny, I., Watras, J. & Ehrlich, B. E. Nature 351, 751–754 (1991).

    Article  ADS  CAS  Google Scholar 

  14. Fleischer, S. & Inui, M. A. Rev. Biophys. biophys. Chem. 18, 333–364 (1989).

    Article  CAS  Google Scholar 

  15. Irvine, R. F. FEBS Lett. 263, 5–9 (1990).

    Article  CAS  Google Scholar 

  16. Finch, E. A., Turner, T. & Goldin, S. M. Science 252, 443–446 (1991).

    Article  ADS  CAS  Google Scholar 

  17. Watras, J., Bezprozvanny, I. & Ehrlich, B. E. J. Neurosci. 11, 3239–3245 (1991).

    Article  CAS  Google Scholar 

  18. Berridge, M. J. J. biol. Chem. 265, 9583–9586 (1990).

    CAS  Google Scholar 

  19. Meyer, T. Cell 64, 675–678 (1991).

    Article  CAS  Google Scholar 

  20. Jaffe, L. F. Proc. natn. Acad. Sci. U.S.A. 88, 9883–9887 (1991).

    Article  ADS  CAS  Google Scholar 

  21. Kasai, H. & Augustine, G. J. Nature 348, 735–738 (1990).

    Article  ADS  CAS  Google Scholar 

  22. Lechleiter, J., Girard, S., Peralta, E. & Clapham, D. Science 252, 123–126 (1991).

    Article  ADS  CAS  Google Scholar 

  23. Iino, M. J. gen. Physiol. 94, 363–383 (1989).

    Article  CAS  Google Scholar 

  24. Downes, C. P., Mussat, M. C. & Michell, R. H. Biochem. J. 203, 169–177 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan

    Masamitsu Iino & Makoto Endo

Authors
  1. Masamitsu Iino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Makoto Endo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iino, M., Endo, M. Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release. Nature 360, 76–78 (1992). https://doi.org/10.1038/360076a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/360076a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing