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Primary structure and functional expression of a mouse inward rectifier potassium channel

Abstract

A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.

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Kubo, Y., Baldwin, T., Nung Jan, Y. et al. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362, 127–133 (1993). https://doi.org/10.1038/362127a0

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