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Role of tissue factor in embryonic blood vessel development

Nature volume 383, pages 73–75 (1996)Cite this article

Abstract

TISSUE factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor for plasma factor Vll/VIIa (ref. 1), is the primary cellular initiator of blood coagulation. It is involved in thrombosis and inflammation associated with sepsis, atherosclerosis and cancer2, and can participate in other cellular processes including intracellular signalling3, metastasis4, tumour-associated angiogenesis5, and embryogenesis6. Here we report that inactivation of the tissue factor gene (TF) results in abnormal circulation from yolk sac to embryo beyond embryonic day 8.5, leading to embryo wasting and death. Vitelline vessels from null mice were deficient in smooth-muscle α-actin-expres-sing mesenchymal cells, which participate in organization of the vessel wall. This implies that tissue factor has a role in bloodvessel development.

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Authors and Affiliations

  1. Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, B-3000, Leuven, Belgium

    Peter Carmeliet, Lieve Moons, Lise Van Vlaenderen & Désiré Collen

  2. Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, California, CA 92037, USA

    Nigel Mackman & Thomas Edgington

  3. Institute of Pathology, Technical University of Dresden, Dresden, 01307, Germany

    Thomas Luther, Michael Kasper & Martin Müller

  4. Laboratoire de Neurologie du Developpement, Höpital Robert Debré, Paris, 75019, France

    Pierre Gressens & Philippe Evrard

  5. Laboratory of Experimental Hematology, University Hospital Leuven, Leuven, B-3000, Belgium

    Hilde Demunck

  6. Max Planck Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-lnstitut, Abteilung Molekulare Zellbiologie, Bad Nauheim, Germany

    Georg Breier & Werner Risau

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  1. Peter Carmeliet
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Carmeliet, P., Mackman, N., Moons, L. et al. Role of tissue factor in embryonic blood vessel development. Nature 383, 73–75 (1996). https://doi.org/10.1038/383073a0

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