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Role of CBP/P300 in nuclear receptor signalling

Nature volume 383, pages 99–103 (1996)Cite this article

Abstract

THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins1,3. An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation4,5. Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcrip-tional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.

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References

  1. Mangelsdorf, D. J. et al. Cell 83, 835–839 (1995).

    Article  CAS  Google Scholar 

  2. Evans, R. M. Science 240, 889–895 (1988).

    Article  ADS  CAS  Google Scholar 

  3. Green, S. & Chambon, P. Trends. Genet. 4, 309–314 (1988).

    Article  CAS  Google Scholar 

  4. Mangelsdorf, D. J. & Evans, R. M. Cell 83, 841–850 (1995).

    Article  CAS  Google Scholar 

  5. Casanova, J. et al. Mol. Cell. Biol. 14, 5756–5765 (1994).

    Article  CAS  Google Scholar 

  6. Chrivia, J. C. et al. Nature 365, 855–859 (1993).

    Article  ADS  CAS  Google Scholar 

  7. Eckner, R. et al. Genes Dev. 8, 869–884 (1994).

    Article  CAS  Google Scholar 

  8. Chen, J. D. & Evans, R. M. Nature 377, 454–457 (1995).

    Article  ADS  CAS  Google Scholar 

  9. Hörlein, A. J. et al. Nature 377, 397–404 (1995).

    Article  ADS  Google Scholar 

  10. Oñate, S. A., Tsai, S. Y., Tsai, M. J. & O'Malley, B. W. Science 270, 1354–1357 (1995).

    Article  ADS  Google Scholar 

  11. Lee, J. W., Ryan, F., Swaffield, J. C., Johnston, S. A. & Moore, D. D. Nature 374, 91–94 (1995).

    Article  ADS  CAS  Google Scholar 

  12. vom Baur, E. et al. EMBO J. 15, 110–124 (1995).

    Article  Google Scholar 

  13. Cavaillès, V. et al. EMBO J. 14, 3741–3751 (1995).

    Article  Google Scholar 

  14. Halachmi, S. et al. Science 264, 1455–1458 (1994).

    Article  ADS  CAS  Google Scholar 

  15. Le Douarin, B. et al. EMBO J. 14, 2020–2033 (1995).

    Article  CAS  Google Scholar 

  16. Schüle, R. & Evans, R. M. Trends Genet. 7, 377–381 (1991).

    Article  Google Scholar 

  17. Arias, J. et al. Nature 370, 226–229 (1994).

    Article  ADS  CAS  Google Scholar 

  18. Hill, C. S. & Treisman, R. Cell 80, 199–211 (1995).

    Article  CAS  Google Scholar 

  19. Schulman, I. G., Chakravarti, D., Juguilon, H., Romo, A. & Evans, R. M. Proc. Natl Acad. Sci. USA 92, 8288–8292 (1995).

    Article  ADS  CAS  Google Scholar 

  20. Parker, D. et al. Mol. Cell. Biol. 16, 694–703 (1996).

    Article  CAS  Google Scholar 

  21. Forman, B. M., Umesono, K., Chen, J. & Evans, R. M. Cell 81, 541–550 (1995).

    Article  CAS  Google Scholar 

  22. Forman, B. M. et al. Cell 81, 687–693 (1995).

    Article  CAS  Google Scholar 

  23. Umesono, K., Murakami, K. K., Thompson, C. C. & Evans, R. M. Cell 65, 1255–1266 (1991).

    Article  CAS  Google Scholar 

  24. Hollenberg, S. M., Giguère, V., Segui, P. & Evans, R. M. Cell 49, 39–46 (1987).

    Article  CAS  Google Scholar 

  25. Kamei, Y. et al. Cell 85, 403–414 (1996).

    Article  CAS  Google Scholar 

  26. Kwok, R. P. S. et al. Nature 380, 642–646 (1996).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. The Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

    Debabrata Chakravarti, Vickie J. LaMorte, Michael C. Nelson, Ira G. Schulman, Henry Juguilon & Ronald M. Evans

  2. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

    Toshihiro Nakajima & Marc Montminy

  3. The Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

    Ronald M. Evans

Authors
  1. Debabrata Chakravarti
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  2. Vickie J. LaMorte
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  3. Michael C. Nelson
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  4. Toshihiro Nakajima
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  5. Ira G. Schulman
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  6. Henry Juguilon
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  7. Marc Montminy
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  8. Ronald M. Evans
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Chakravarti, D., LaMorte, V., Nelson, M. et al. Role of CBP/P300 in nuclear receptor signalling. Nature 383, 99–103 (1996). https://doi.org/10.1038/383099a0

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