Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Zinc, Src and NMDA receptors—a transmembrane connection

Nature Neuroscience volume 1, pages 173–175 (1998)Cite this article

Abstract

Zinc and tyrosine kinases produce opposite effects on the NMDA receptor; new evidence suggests that Src-induced potentiation is due to the relief of zinc inhibition.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Left: the NMDA receptor has been activated by the simultaneous binding of glycine to the NR1 subunit and of glutamate to the NR2A subunit, but the binding of zinc reduces the time spent in the open state.

References

  1. Frederickson, C.J. Intl. Rev. Neurobiol. 131, 145–238 (1989).

    Article  Google Scholar 

  2. Legendre, P., & Westbrook, G.L. J. Physiol. (Lond.) 429, 429–449 (1990).

    Article  CAS  Google Scholar 

  3. Christine, C.W. & Choi, D.W. J. Neurosci. 10, 108–116 (1990).

    Article  CAS  Google Scholar 

  4. Paoletti, P., Ascher, P. & Neyton, J. J.Neurosci. 17, 5711–5725 (1997).

    Article  CAS  Google Scholar 

  5. Williams, K., Neurosci. Lett. 215, 9–12 ( 1996).

    Article  CAS  Google Scholar 

  6. Chen, N., Moshaver, A. & Raymond, L.A. Mol. Pharmacol. 51, 1015–1023 (1997).

    Article  CAS  Google Scholar 

  7. Wang, Y.T. & Salter, M.W. Nature 369, 233–235 (1994).

    Article  CAS  Google Scholar 

  8. Yu, X.M., Askalan, R., Keil, G.J. & Salter, M.W. Science 275, 674–678 (1997).

    Article  CAS  Google Scholar 

  9. Köhr, G. & Seeburg, P.H. J. Physiol. (Lond.) 492, 445–452 (1996).

    Article  Google Scholar 

  10. Lu, Y.M., Roder, J.C., Davidow, J. & Salter, M.W. Science 279, 1363–1368 (1998).

    Article  CAS  Google Scholar 

  11. Zheng, F., Gingrich, M.B., Traynelis, S.F. & Conn, P.J. Nature Neurosci. 3, 185–191 ( 1998).

    Article  Google Scholar 

  12. Traynelis, S.F., Burgess, M.F., Zheng, F., Lyuboslavsky, P. & Powers, J.L. J. Neurosci. (in press).

  13. Budde, T., Minta, A., White, J.A. & Kay, A.R. Nature Neuroscience 79, 347–358 (1997).

    CAS  Google Scholar 

  14. Wenzel, H.J., Cole, T.B., Born, D.E., Schwartzkroin, P.A. & Palmiter, R.D. Proc. Natl. Acad. Sci. USA 4, 12676–12681 (1997).

    Article  Google Scholar 

  15. Choi D.W. & Koh, J.Y Annu. Rev. Neurosci. 21 , 347–375 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Neurobiologie, Ecole Normale Superieure, 46 rue d'Ulm, Paris, 75005, France

    Philippe Ascher

Authors
  1. Philippe Ascher
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ascher, P. Zinc, Src and NMDA receptors—a transmembrane connection. Nat Neurosci 1, 173–175 (1998). https://doi.org/10.1038/619

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/619

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing