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Inhaled bronchodilator use for infants with bronchopulmonary dysplasia

Journal of Perinatology volume 35, pages 61–66 (2015)Cite this article

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Abstract

Objective:

To identify factors associated with bronchodilator administration to infants with bronchopulmonary dysplasia (BPD) and evaluate inter-institutional prescribing patterns.

Study Design:

A retrospective cohort study of <29-week-gestation infants with evolving BPD defined at age 28 days within the Pediatric Health Information System database. Controlling for observed confounding with random-effects logistic regression, we determined demographic and clinical variables associated with bronchodilator use and evaluated between-hospital variation.

Result:

During the study period, 33% (N=469) of 1429 infants with BPD received bronchodilators. Lengthening mechanical ventilation duration increased the odds of receiving a bronchodilator (odds ratio 19.6 (11 to 34.8) at ⩾54 days). There was profound between-hospital variation in use, ranging from 0 to 81%.

Conclusion:

Bronchodilators are frequently administered to infants with BPD at US children’s hospitals with increasing use during the first hospital month. Increasing positive pressure exposure best predicts bronchodilator use. Frequency and treatment duration vary markedly by institution even after adjustment for confounding variables.

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Acknowledgements

This study was supported in part by the National Heart, Lung and Blood Institute grant K08HL121182 (Slaughter). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. The Department of Pediatrics, The Ohio State University College of Medicine and Nationwide Children’s Hospital, Columbus, OH, USA

    J L Slaughter, M R Stenger & S R Jadcherla

  2. The Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA

    J L Slaughter, P B Reagan & S R Jadcherla

  3. The Department of Economics, The Ohio State University, Columbus, OH, USA,

    P B Reagan

  4. Center for Human Resource Research, The Ohio State University, Columbus, OH, USA

    P B Reagan

  5. The Neonatal and Infant Feeding Disorders Research Program, Nationwide Children’s Hospital, Columbus, OH, USA

    S R Jadcherla

Authors
  1. J L Slaughter
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  2. M R Stenger
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  4. S R Jadcherla
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Correspondence to J L Slaughter.

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Slaughter, J., Stenger, M., Reagan, P. et al. Inhaled bronchodilator use for infants with bronchopulmonary dysplasia. J Perinatol 35, 61–66 (2015). https://doi.org/10.1038/jp.2014.141

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