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Peptide modulators of protein–protein interactions in intracellular signaling

Nature Biotechnology volume 16, pages 919–924 (1998)Cite this article

Abstract

Signal transduction cascades involve multiple enzymes and are orchestrated by selective protein–protein interactions that are essential for the progression of intracellular signaling events. Modulators of these protein–protein interactions have been used to dissect the role of individual components of each signaling cascade. We describe several methods that have been developed for the identification of pep-tides that inhibit the interaction between signaling proteins and hence selectively modulate their functions. Such peptide modulators provide important tools for basic research and have great potential as leads for the development of new classes of therapeutic drugs.

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Author notes

  1. Daria Mochly-Rosen: Corresponding author (e-mail: mochly@stanford.edu).

Authors and Affiliations

  1. Department of Molecular Pharmacology, Stanford University, School of Medicine, Stanford, CA, 94305-5332

    Miriam C. Souroujon & Daria Mochly-Rosen

  2. The Open University of Israel, Tel Aviv, 61392, Israel

    Miriam C. Souroujon

Authors
  1. Miriam C. Souroujon
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  2. Daria Mochly-Rosen
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Souroujon, M., Mochly-Rosen, D. Peptide modulators of protein–protein interactions in intracellular signaling. Nat Biotechnol 16, 919–924 (1998). https://doi.org/10.1038/nbt1098-919

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