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Integrin regulation of growth factor receptors

Nature Cell Biology volume 4, pages E75–E76 (2002)Cite this article

Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.

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Figure 1: Integrin collaboration compared to direct integrin 'activation' of growth factor receptors.

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Authors and Affiliations

  1. the Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, 20892, MD, USA

    Kenneth M. Yamada & Sharona Even-Ram

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  1. Kenneth M. Yamada
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  2. Sharona Even-Ram
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Yamada, K., Even-Ram, S. Integrin regulation of growth factor receptors. Nat Cell Biol 4, E75–E76 (2002). https://doi.org/10.1038/ncb0402-e75

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