Protein S-nitrosylation is thought to be mediated primarily by nitric oxide synthases. S-nitrosylated GAPDH is now shown to function within signal transduction cascades as a nuclear nitrosylase. Along with other recent demonstrations of regulated protein–protein transnitrosylation, these findings point to a new mechanism of signal transduction with transformative implications for nitric oxide biology and redox signalling.
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Stamler, J., Hess, D. Nascent nitrosylases. Nat Cell Biol 12, 1024–1026 (2010). https://doi.org/10.1038/ncb1110-1024
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DOI: https://doi.org/10.1038/ncb1110-1024
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