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Sorting nexins provide diversity for retromer-dependent trafficking events

Nature Cell Biology volume 14, pages 29–37 (2012)Cite this article

Abstract

Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have fundamental roles in orchestrating cargo sorting through the membranous maze that is the endosomal network. One ancient group of complexes that contain sorting nexins is the retromer. Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development and homeostasis of normal tissues.

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Figure 1: Sorting itineraries in the mammalian endosomal network and the distinct SNX-BAR-retromer and SNX3-retromer complexes.
Figure 3: Spatial segregation model to account for differential cargo sorting through SNX3-retromer and SNX-BAR-retromer pathways.
Figure 2: A proposed pathway for SNX-BAR-retromer-mediated sorting.

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Acknowledgements

We are indebted to J. van Weering for figures. We thank G. Banting, D. Billadeau, M. Harterink, W. Hong, J. Hurley, M. Lorenowicz, I. McGough, S. Munro, M. Seaman, F. Steinberg, D. Stephens, J. van Weering and L. Weismann for thought-provoking discussions. Work in the authors' laboratories are supported by the Wellcome Trust (089928/Z/09/Z and 085743 to P.J.C.) and the Dutch Cancer Society (HUBR 2008-4114) and a NWO VIDI fellowship (016.076.317 to H.C.K.).

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Authors and Affiliations

  1. Peter J. Cullen is at the Henry Wellcome Integrated Signalling Laboratories, School of Biochemistry, Medical Sciences Building, University Walk, University of Bristol, Bristol, BS8 1TD, UK,

    Peter J. Cullen

  2. Hendrik C. Korswagen is at the Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands,

    Hendrik C. Korswagen

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  1. Peter J. Cullen
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Correspondence to Peter J. Cullen or Hendrik C. Korswagen.

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Cullen, P., Korswagen, H. Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol 14, 29–37 (2012). https://doi.org/10.1038/ncb2374

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