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The ying and yang of rifampicin

The binding of rifampicin to the human glucocorticoid receptor explains how this antibiotic exerts its immunosuppressive effects (pages 92–96).

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References

  1. Mitchison, D.A. The action of antituberculosis drugs in short-course chemotherapy. Tubercle 66, 219–226 (1985).

    Article  CAS  Google Scholar 

  2. Bloom, B.R. & Murray, C.J.L., Commentary on a re-emergent killer. Science 257, 1055–1064 (1992).

    Article  CAS  Google Scholar 

  3. Grosset, J. & Leventis, S. Adverse effects of rifampin. Rev. Infect. Dis. 5, Supplement 3, S440–446 (1983).

    Article  CAS  Google Scholar 

  4. Calleja, C., Pascussi, J.M., Mani, J.C., Maurel, P. & Vilarem, M.J. The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor. Nature Med. 4, 92–96 (1998).

    Article  CAS  Google Scholar 

  5. Miller, L.P., Crawford, J.T. & Shinnick, T.M. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38, 805–811 (1994).

    Article  CAS  Google Scholar 

  6. Zilly, W., Breimer, D.D. & Richter, E. Induction of drug metabolism in man after rifampicin treatment measured by incresed hexobarbital and tolbutamide clearance. Eur. J. Gin. Pharmacol. 9, 219–227 (1977).

    Google Scholar 

  7. Barry, M., Gibbons, S., Back, D. & Mulcahy, F. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clinical Pharmacokinetics 32, 194–209 (1997).

    Article  CAS  Google Scholar 

  8. Heifets, L.B., Lindholm-Levy, P.J. & Flory, M.A. Bactericidal activity in vitro of various rifamycins against Mycobacterium avium and Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 141, 626–630 (1990).

    Article  CAS  Google Scholar 

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Blanchard, J. The ying and yang of rifampicin. Nat Med 4, 14–15 (1998). https://doi.org/10.1038/nm0198-014

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