The binding of rifampicin to the human glucocorticoid receptor explains how this antibiotic exerts its immunosuppressive effects (pages 92–96).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mitchison, D.A. The action of antituberculosis drugs in short-course chemotherapy. Tubercle 66, 219–226 (1985).
Bloom, B.R. & Murray, C.J.L., Commentary on a re-emergent killer. Science 257, 1055–1064 (1992).
Grosset, J. & Leventis, S. Adverse effects of rifampin. Rev. Infect. Dis. 5, Supplement 3, S440–446 (1983).
Calleja, C., Pascussi, J.M., Mani, J.C., Maurel, P. & Vilarem, M.J. The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor. Nature Med. 4, 92–96 (1998).
Miller, L.P., Crawford, J.T. & Shinnick, T.M. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38, 805–811 (1994).
Zilly, W., Breimer, D.D. & Richter, E. Induction of drug metabolism in man after rifampicin treatment measured by incresed hexobarbital and tolbutamide clearance. Eur. J. Gin. Pharmacol. 9, 219–227 (1977).
Barry, M., Gibbons, S., Back, D. & Mulcahy, F. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clinical Pharmacokinetics 32, 194–209 (1997).
Heifets, L.B., Lindholm-Levy, P.J. & Flory, M.A. Bactericidal activity in vitro of various rifamycins against Mycobacterium avium and Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 141, 626–630 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Blanchard, J. The ying and yang of rifampicin. Nat Med 4, 14–15 (1998). https://doi.org/10.1038/nm0198-014
Issue Date:
DOI: https://doi.org/10.1038/nm0198-014
This article is cited by
-
Reply to Rifampicin: a glucocorticoid receptor ligand?
Nature Medicine (1998)
-
Rifampicin: a glucocorticoid receptor ligand?
Nature Medicine (1998)