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Osteopetrosis in mice lacking NF-κB1 and NF-κB2

Nature Medicine volume 3, pages 1285–1289 (1997)Cite this article

Abstract

The nfkbl and nfkb2 genes encode closely related products regulating immune and inflammatory responses1–3. Their role during development and differentiation remains unclear. The generation of nfkb1 null mice (p50−/−) resulted in altered immune responses, but had no effect on development4. Similarly, nfkb2 knockout mice (p52−/−) did not show developmental defects (J.C. et al., manuscript submitted). We have investigated the potential for in vivo compensatory functions of these genes by generating double-knockout mice. The surprising result was that the animals developed osteopetrosis because of a defect in osteoclast differentiation, suggesting redundant functions of NF-κB1 and NF-κB2 proteins in the development of this cell lineage. The osteopetrotic phenotype was rescued by bone marrow transplantation, indicating that the hematopoietic component was impaired. These results define a new mouse osteopetrotic mutant and implicate NF-κB proteins in bone development, raising new directions in the treatment of bone disorders.

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Authors and Affiliations

  1. Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey, 08543-4000, USA

    Violetta Iotsova, Jorge Caamaño, Yi Yang, Anne Lewin & Rodrigo Bravo

  2. Department of Experimental Pathology, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey, 08543-4000, USA

    James Loy

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  1. Violetta Iotsova
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Iotsova, V., Caamaño, J., Loy, J. et al. Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nat Med 3, 1285–1289 (1997). https://doi.org/10.1038/nm1197-1285

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