Abstract
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide–containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
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Acknowledgements
We thank C. Voigts for the preparation of the illustrations, and B. Oldörp and C. Wiegand-Löhnert for their critical comments on the manuscript. The authors are supported by the Deutsche Forschungsgemeinschaft (KFO 100, GRK 276, STE 477), the International Anesthesia Research Society (Frontiers in Anesthesia Research Program), the Bundesministerium für Bildung und Forschung (01GZ0311) and the Freie Universität Berlin (Research Program Inflammatory Diseases).
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Stein, C., Schäfer, M. & Machelska, H. Attacking pain at its source: new perspectives on opioids. Nat Med 9, 1003–1008 (2003). https://doi.org/10.1038/nm908
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DOI: https://doi.org/10.1038/nm908
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