Abstract
Following brief stimulation, macroscopic NMDA receptor currents decay with biphasic kinetics that is believed to reflect glutamate dissociation and receptor desensitization. We found that the fast and slow decay components arise from the simultaneous deactivation of receptor populations that gate with short and long openings, respectively. Because individual receptors switched infrequently between gating modes, the relaxation time course was largely determined by the proportion of channels in each gating mode at the time of stimulation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McBain, C.J. & Mayer, M.L. Physiol. Rev. 74, 723–760 (1994).
Lester, R.A., Clements, J.D., Westbrook, G.L. & Jahr, C.E. Nature 346, 565–567 (1990).
Lester, R.A. & Jahr, C.E. J. Neurosci. 12, 635–643 (1992).
Popescu, G. & Auerbach, A. Nat. Neurosci. 6, 476–483 (2003).
Popescu, G., Robert, A., Howe, J.R. & Auerbach, A. Nature 430, 790–793 (2004).
Banke, T.G. & Traynelis, S.F. Nat. Neurosci. 6, 144–152 (2003).
Colquhoun, D. & Hawkes, A.G. Proc. R. Soc. Lond. B 211, 205–235 (1981).
Schorge, S., Elenes, S. & Colquhoun, D. J. Physiol. 569, 395–418 (2005).
Auerbach, A. & Zhou, Y. J. Neurosci. 25, 7914–7923 (2005).
Erreger, K., Dravid, S.M., Banke, T.G., Wyllie, D.J.A. & Traynelis, S.F. J. Physiol. (Lond.) 563, 345–358 (2005).
Vicini, S. et al. J. Neurophysiol. 79, 555–566 (1998).
Wyllie, D.J., Behe, P. & Colquhoun, D. J. Physiol. (Lond.) 510, 1–18 (1998).
Stocca, G. & Vicini, S. J. Physiol. (Lond.) 507, 13–24 (1998).
Priestley, T., Ochu, E. & Kemp, J.A. Neuroreport 5, 1763–1765 (1994).
Zhong, J., Russell, S.L., Pritchett, D.B., Molinoff, P.B. & Williams, K. Mol. Pharmacol. 45, 846–853 (1994).
Acknowledgements
This work was supported in part by grants from the US National Institutes of Health (to J.R.H. and G.K.P.), the American Heart Association (to G.K.P.) and a travel grant from the Department of Anesthesiology (to G.K.P.).
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Supplementary Text and Figures
Supplementary Figure 1, Supplementary Table 1, Supplementary Methods and Supplementary Results (PDF 251 kb)
Rights and permissions
About this article
Cite this article
Zhang, W., Howe, J. & Popescu, G. Distinct gating modes determine the biphasic relaxation of NMDA receptor currents. Nat Neurosci 11, 1373–1375 (2008). https://doi.org/10.1038/nn.2214
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2214
This article is cited by
-
A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability
Nature Communications (2018)
-
NMDA receptors: linking physiological output to biophysical operation
Nature Reviews Neuroscience (2017)
-
The structure–energy landscape of NMDA receptor gating
Nature Chemical Biology (2017)
-
Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation
Scientific Reports (2016)
-
Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels
Nature Structural & Molecular Biology (2016)
