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A-kinase anchoring proteins in amygdala are involved in auditory fear memory

Nature Neuroscience volume 5, pages 837–838 (2002)Cite this article

A Corrigendum to this article was published on 01 October 2002

Abstract

A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation1,2,3,4. Here we show that the regulatory subunits of PKA are colocalized with AKAP150 (an AKAP isoform that is expressed in the brain)5 in the lateral amygdala (LA) and that infusion to the LA of the peptide St-Ht31, which blocks PKA anchoring onto AKAPs, impairs memory consolidation of auditory fear conditioning.

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Figure 1: Colocalization of RIIα and RIIβ with AKAP150 in the lateral amygdala.
Figure 2: St-Ht31 blocks the consolidation of auditory fear memories.

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Acknowledgements

We thank G. Schafe and T. Blair for comments and C. Farb for technical support. M.A.P.M. was supported by the Gulbenkian Foundation and Program PRAXIS XXI/FCT under the Programa Gulbenkian de Doutoramento em Biologia e Medicina. R.L. was supported by a post-doctoral fellowship from the Human Frontier Science Program. National Institute for Mental Health grants MH38774, MH46516 and MH00956 to J.E.L.

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  1. W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, 10003, USA

    Marta A.P. Moita, Raphael Lamprecht, Karim Nader & Joseph E. LeDoux

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  1. Marta A.P. Moita
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  2. Raphael Lamprecht
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Correspondence to Joseph E. LeDoux.

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Moita, M., Lamprecht, R., Nader, K. et al. A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat Neurosci 5, 837–838 (2002). https://doi.org/10.1038/nn901

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