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Fortuitous convergences: the beginnings of JUN

Nature Reviews Cancer volume 2, pages 465–469 (2002)Cite this article

Abstract

The oncogenic cellular phenotype reflects transcriptional and post-transcriptional changes in gene expression. The popular technique of expression profiling with microarrays highlights that changes in messenger RNA levels are important determinants of oncogenicity. The idea that upregulation and downregulation of specific crucial target genes can cause cancer derives from the discovery of oncogenic transcription factors. So, how was JUN — the first oncogenic transcription factor — discovered?

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Figure 1: The JUN pioneers.
Figure 2: Deregulated Jun.

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Acknowledgements

Work of the author is supported by grants from the National Cancer Institute. This is manuscript number MEM 14965 of The Scripps Research Institute.

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Authors and Affiliations

  1. the Division of Oncovirology, The Scripps Research Institute, 10550 N. Torrey Pines Road BCC239, La Jolla, 92037, California, USA

    Peter K. Vogt

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  1. Peter K. Vogt
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DATABASES

GenBank

avian sarcoma virus 17

SV40

LocusLink

ABL

ATF family

BCR

C/EBP

DNase I

FKHR

Fos

FOS

FOS-B

Fra1

Fra2

Jun

JUN

Jun-B

Jun-D

metallothionein 2A

p53

PAX3

PML

RARα

<i>Saccharomyces</i> Genome Database

Gcn4

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Vogt, P. Fortuitous convergences: the beginnings of JUN. Nat Rev Cancer 2, 465–469 (2002). https://doi.org/10.1038/nrc818

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