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Role of redox potential and reactive oxygen species in stress signaling

Oncogene volume 18, pages 6104–6111 (1999)Cite this article

Abstract

Stress-activated signaling cascades are affected by altered redox potential. Key contributors to altered redox potential are reactive oxygen species (ROS) which are formed, in most cases, by exogenous genotoxic agents including irradiation, inflammatory cytokines and chemical carcinogens. ROS and altered redox potential can be considered as the primary intracellular changes which regulate protein kinases, thereby serving as an important cellular component linking external stimuli with signal transduction in stress response. The mechanisms, which underlie the ROS-mediated response, involve direct alteration of kinases and transcription factors, and indirect modulation of cysteine-rich redox-sensitive proteins exemplified by thioredoxin and glutathione S-transferase. This review summarizes the current understanding of the mechanisms contributing to ROS-related changes in key stress activated signaling cascades.

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Abbreviations

ASK:

apoptosis signal-regulating kinase

ERK:

extracellular signal regulated kinase

GR:

glucocorticoid receptor NO -nitric oxide

GST:

glutathione S-transferase

IRP:

iron responsive protein

JNK:

Jun NH2 terminal kinase

MAPK:

mitogen activated protein kinase

Ng:

neurogranin

PI3K:

phosphoinositol 3 kinase

PKC:

protein kinase C

ROS:

reactive oxygen species

TNF:

tumor necrosis factor

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Acknowledgements

We thank Serge Fuchs for helpful comments. Support by NIH grant CA77389 (to Z Ronai) is gratefully acknowledged.

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  1. Ruttenberg Cancer Center, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1130, New York, 10029, NY, USA

    Victor Adler, Zhimin Yin & Ze'ev Ronai

  2. Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Kenneth D Tew

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Adler, V., Yin, Z., Tew, K. et al. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18, 6104–6111 (1999). https://doi.org/10.1038/sj.onc.1203128

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