Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

From receptors to stress-activated MAP kinases

Oncogene volume 18, pages 6087–6093 (1999)Cite this article

Abstract

The cell signaling pathways that culminate in activation of a family of stress-activated MAP kinases are beginning to be defined. Determination of cell life and cell death is known to largely depend on the balance of intrinsic life and death signals within cells. Recently, two representative mammalian stress-activated kinases, the JNK and p38 MAP kinases, have been implicated in determination of cell fate by modifying the life, death and differentiation signals. However, the molecular mechanisms by which extracellular signals are transmitted from membrane receptors to the most upstream kinases in the JNK and p38 signaling modules are not fully understood. This review will provide an overview of current knowledge of molecular links between inflammatory cyokine receptors and stress-activated MAP kinase cascades.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B and Minden A. . 1998 EMBO J. 17: 6527–6540.

  • Aoki M, Akiyama T, Miyoshi J and Toyoshima K. . 1991 Oncogene 6: 1515–1519.

  • Ashkenazi A and Dixit VM. . 1998 Science 281: 1305–1308.

  • Baeuerle PA and Baltimore D. . 1996 Cell 87: 13–20.

  • Bagrodia S, Derijard B, Davis RJ and Cerione RA. . 1995 J. Biol. Chem. 270: 27995–27998.

  • Baker SJ and Reddy EP. . 1998 Oncogene 17: 3261–3271.

  • Baud V, Liu Z-G, Bennet B, Suzuki N, Xia Y and Karin M. . 1999 Genes Dev. 13: 1297–1308.

  • Belich MP, Salmeron A, Johnson LH and Ley SC. . 1999 Nature 397: 363–368.

  • Blank JL, Gerwins P, Elliott EM, Sather S and Johnson GL. . 1996 J. Biol. Chem. 271: 5361–5368.

  • Brenner DA, O'Hara M, Angel P, Chojkier M and Karin M. . 1989 Nature 337: 661–663.

  • Cao Z, Xiong J, Takeuchi M, Kurama T and Goeddel DV. . 1996 Nature 383: 443–446.

  • Cardone MH, Salvesen GS, Widmann C, Johnson G and Frisch SM. . 1997 Cell 90: 315–323.

  • Chang H, Nishitoh H, Yang X, Ichijo H and Baltimore D. . 1998 Science 281: 1860–1863.

  • Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S and Baltimore D. . 1995 Science 267: 1494–1498.

  • Creasy CL and Chernoff J. . 1995 J. Biol. Chem. 270: 21695–21700.

  • Davis RJ. . 1994 Trends Biochem. Sci 19: 470–473.

  • Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ and Davis RJ. . 1995 Science 267: 682–685.

  • Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan T-H and Yao Z. . 1997 Proc. Natl. Acad. Sci. USA 94: 9687–9692.

  • Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR and Simpson RJ. . 1995 Eur. J. Biochem. 234: 492–500.

  • Errede B and Levin DE. . 1993 Curr. Opin. Cell Biol. 5: 254–260.

  • Fanger GR, Johnson NL and Johnson GL. . 1997 EMBO J. 16: 4961–4972.

  • Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q and Godowski PJ. . 1994 J. Biol. Chem. 269: 15092–15100.

  • Gerwins P, Blank J and Johnson GL. . 1997 J. Biol. Chem. 272: 8288–8295.

  • Goedert M, Cuenda A, Craxton M, Jakes R and Cohen P. . 1997 EMBO J. 16: 3563–3571.

  • Gotoh Y and Cooper JA. . 1998 J. Biol. Chem. 273: 17477–17482.

  • Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DKM, Wright M, Chernoff J, Clark EA and Krebs EG. . 1998 EMBO J. 17: 2224–2234.

  • Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B and Davis RJ. . 1996 EMBO J. 15: 2760–2770.

  • Han J, Lee JD, Bibbs L and Ulevitch RJ. . 1994 Science 265: 808–811.

  • Hirai S, Izawa M, Osada S, Spyrou G and Ohno S. . 1996 Oncogene 12: 641–650.

  • Hirai S, Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J and Ohno S. . 1997 J. Biol. Chem. 272: 15167–15173.

  • Holland PM, Suzanne M, Campbell JS, Noselli S and Cooper JA. . 1997 J. Biol. Chem. 272: 24994–24998.

  • Holzman LB, Merritt SE and Fan G. . 1994 J. Biol. Chem. 269: 30808–30817.

  • Hsu H, Xiong J and Goeddel DV. . 1995 Cell 81: 495–504.

  • Hsu H, Huang J, Shu HB, Baichwal V and Goeddel DV. . 1996a Immunity 4: 387–396.

  • Hsu H, Shu HB, Pan MG and Goeddel DV. . 1996b Cell 84: 299–308.

  • Hu HM, O'Rourke K, Boguski MS and Dixi VM. . 1994 J. Biol. Chem. 269: 30069–30072.

  • Hu MC, Qiu WR, Wang X, Meyer CF and Tan T-H. . 1996 Genes Dev. 15: 2251–2264.

  • Ichijo H, Nishida E, Irie K, ten Dijike P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y. . 1997 Science 275: 90–94.

  • Ing YL, Leung IW, Heng HH, Tsui L and Lassam NJ. . 1994 Oncogene 9: 1745–1750.

  • Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di PF, Ulevitch RJ and Han J. . 1997 J. Biol. Chem. 272: 30122–30128.

  • Katz P, Whalen G and Kehrl JH. . 1994 J. Biol. Chem. 269: 16802–16809.

  • Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ and Leder P. . 1998 Cell 87: 565–576.

  • Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodget JR and Iscove NN. . 1996 EMBO J. 15: 7013–7025.

  • Knaus UG, Morris S, Dong HJ, Chernoff J and Bokoch GM. . 1995 Science 269: 221–223.

  • Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E and Karasuyama H. . 1997 J. Biol. Chem. 272: 22679–22684.

  • Kyriakis JM. . 1999 J. Biol. Chem. 274: 5259–5262.

  • Kyriakis JM and Avruch J. . 1996 J. Biol. Chem. 271: 24313–24316.

  • Lange CC, Pleiman CM, Gardner AM, Blumer KJ and Johnson GL. . 1993 Science 260: 315–319.

  • Lee JC, Laydon JT, McDonnell PC, Gallaghe TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL and Youg PR. . 1994 Nature 372: 739–746.

  • Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC and Choi Y. . 1997 Immunity 7: 703–713.

  • Lin X, Cunningham Jr ET, Mu Y, Geleziunas R and Greene WC. . 1999 Immunity 10: 271–280.

  • Liu ZG, Hsu H, Goeddel DV and Karin M. . 1996 Cell 87: 565–576.

  • Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV and Mak TW. . 1999 Genes Dev. 15: 1015–1024.

  • Malinin NL, Boldin MP, Kovalenko AV and Wallach D. . 1997 Nature 385: 540–544.

  • Manser E, Leung T, Salihuddin H, Zhao ZS and Lim L. . 1994 Nature 367: 40–46.

  • Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K and Nishida E. . 1996 J. Biol. Chem. 271: 26981–26988.

  • Moriguchi T, Toyoshima F, Masuyama N, Hanafusa H, Gotoh Y and Nishida E. . 1997 EMBO J. 16: 7045–7053.

  • Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C and Kieff E. . 1995 Cell 80: 389–399.

  • Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N and Hall A. . 1998 EMBO J. 17: 149–158.

  • Nagata S. . 1997 Cell 88: 355–365.

  • Nakano H, Oshima H, Chung W, Williams AL, Ware CF, Yagita H and Okumura K. . 1996 J. Biol. Chem. 271: 14661–14664.

  • Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H and Okumura K. . 1998 Proc. Natl. Acad. Sci. USA 95: 3537–3542.

  • Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee SM, Ware CF, Rennert PD, Taniguchi M, Yagita H and Okumura K. . 1999 Proc. Natl. Acad. Sci. USA 96: 9803–9808.

  • Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett JR, Balsano C and Levrero M. . 1997 Science 275: 200–203.

  • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J-i, Cao Z and Matsumoto K. . 1999 Nature 398: 252–256.

  • Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K and Ichijo H. . 1998 Molec. Cell 2: 389–395.

  • Pombo CM, Bonventre JV, Molnar A, Kyriakis J and Force T. . 1996 EMBO J. 15: 4537–4546.

  • Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM and Avruch J. . 1996 J. Biol. Chem. 271: 19025–19028.

  • Reddy UR and Pleasure D. . 1994 Biochem. Biophys. Res. Commun. 202: 613–620.

  • Régnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P and Rio MC. . 1995 J. Biol. Chem. 270: 25715–25721.

  • Reinhard C, Shamoon B, Shyamala V and Williams LT. . 1997 EMBO J. 16: 1080–1092.

  • Rothe M, Wong SC, Henzel WJ and Goeddel DV. . 1994 Cell 78: 681–692.

  • Rothe M, Sarma V, Dixit VM and Goeddel DV. . 1995a Science 269: 1424–1427.

  • Rothe M, Pan MG, Henzel WJ, Ayres TM and Goeddel DV. . 1995b Cell 83: 1243–1252.

  • Rudel T and Bokoch GM. . 1997 Science 276: 1571–1574.

  • Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K and Ichijo H. . 1998 EMBO J. 17: 2596–2606.

  • Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP and Ley SC. . 1996 EMBO J. 15: 817–826.

  • Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis J and Zon LI. . 1994 Nature 372: 794–798.

  • Schaeffer HJ, Calting AD, Eblen ST, Collier LS, Kraus A and Weber MJ. . 1998 Science 281: 1668–1671.

  • Schaeffer HJ and Weber M. . 1999 Mol. Cell. Biol. 19: 2435–2444.

  • Schinkmann K and Blenis J. . 1997 J. Biol. Chem. 272: 28695–28703.

  • Shi C-S and Kehrl JH. . 1997 J. Biol. Chem. 272: 32102–32107.

  • Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K and Nishida E. . 1997 J. Biol. Chem. 272: 8141–8144.

  • Shu HB, Takeuchi M, and Goeddel DV. . 1996 Proc. Natl. Acad. Sci. USA 93: 13973–13978.

  • Song HY, Régnier CH, Kirschning CJ, Goeddel DV and Rothe M. . 1997 Proc. Natl. Acad. Sci. USA 94: 9792–9796.

  • Stein B, Brady H, Yang MX, Young DB and Barbosa MS. . 1996 J. Biol. Chem. 271: 11427–11433.

  • Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW and Barbosa MS. . 1997 J. Biol. Chem. 272: 19509–19517.

  • Su Y-C, Han J, Xu S, Cobb M and Skolnik EY. . 1997 EMBO J. 16: 1279–1290.

  • Takekawa M, Posas F and Saito H. . 1997 EMBO J. 16: 4973–4982.

  • Takekawa M and Saito H. . 1998 Cell 95: 521–530.

  • Takeuchi M, Rothe M and Goeddel DV. . 1996 J. Biol. Chem. 271: 19935–19942.

  • Tartaglia LA and Goeddel DV. . 1992 Immunol. Today 13: 151–153.

  • Taylor LK, Wang H-C and Erikson RL. . 1996 Proc. Natl. Acad. Sci. USA 93: 10099–10104.

  • Ting AT, Pimentel-Muinos FX and Seed B. . 1996 EMBO J. 15: 6189–6196.

  • Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T and Davis RJ. . 1997 Proc. Natl. Acad. Sci. USA 94: 7337–7342.

  • Tung RM and Blenis J. . 1997 Oncogene 14: 653–659.

  • Wallach D, Varfolomeev EE, Malinin NL, Yuri Goltsev V, Kovalenko AV and Boldin MP. . 1999 Annu. Rev. Immunol. 17: 331–367.

  • Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M and Yao Z. . 1996 J. Biol. Chem. 271: 31607–31611.

  • Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan HP, Mantlo N, Lichenstein HS, Zukowski M and Yao Z. . 1997 J. Biol. Chem. 272: 23668–23674.

  • Wang XS, Diener K, Tan TH and Yao Z. . 1998 Biochem. Biophys. Res. Commun. 253: 33–37.

  • Waskiewicz AJ and Cooper JA. . 1995 Curr. Opin. Cell Biol. 7: 798–805.

  • Whitmarsh AJ and Davis RJ. . 1998 Trends Biochem. Sci. 23: 481–485.

  • Whittmarsh AJ, Cavanagh J, Tournier C, Yasuda J and Davis R. . 1998 Science 281: 1671–1674.

  • Widmann C, Gibson S, Jarpe MB and Johnson GL. . 1999 Physiol. Rev. 79: 143–180.

  • Wu Z, Wu J, Jacinto E and Karin M. . 1997 Mol. Cell. Biol. 17: 7407–7416.

  • Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E and Matsumoto K. . 1995 Science 270: 2008–2011.

  • Yang X, Khosravi-Far HY, Chang H and Baltimore D. . 1997 Cell 89: 1067–1076.

  • Yao Z, Diener K, Wang XS, Zukowski M, Matsumoto G, Zhou G, Mo R, Sasaki T, Nishina H, Hui CC, Tan TH, Woodgett JP and Penninger JM. . 1997 J. Biol. Chem. 272: 32378–32383.

  • Yao Z, Zhou G, Wang XS, Brown A, Diener K, Gan H and Tan T-H. . 1999 J. Biol. Chem. 274: 2118–2125.

  • Yeh W-C, Shahinian A, Speiser D, Kraunus J, Billia F, Wakeham A, Pompa JL, Ferrick D, Hum B, Iscove N, Ohashi P, Rothe M, Goeddel DV and Mak TW. . 1997 Immunity 7: 715–725.

  • Yuasa T, Ohno S, Kehrl JH and Kyriakis JM. . 1998 J. Biol. Chem. 273: 22681–22692.

  • Zhao Q and Lee FS. . 1999 J. Biol. Chem. 274: 8355–8358.

Download references

Acknowledgements

Thanks to John Kyriakis, Hong Liu and Hiroyasu Nakano for collaboration and for providing results prior to publication, also to Kohei Miyazono and all the members of my laboratory, especially, Masao Saitoh, Hideki Nishitoh, Kei Tobiume, Yasuhiro Sawada and Kohsuke Takeda for stimulating discussion, and Keiko Tatsumi for her excellent help in preparation of the manuscript. I regret being unable to cite many important papers due to limited space.

Author information

Authors and Affiliations

  1. Department of Biomaterials Science, Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hidenori Ichijo

Authors
  1. Hidenori Ichijo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ichijo, H. From receptors to stress-activated MAP kinases. Oncogene 18, 6087–6093 (1999). https://doi.org/10.1038/sj.onc.1203129

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203129

Keywords

This article is cited by

Search

Advanced search

Quick links