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  • Original Paper
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Control of myeloid differentiation and survival by Stats

Oncogene volume 19, pages 2612–2618 (2000)Cite this article

Abstract

Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hematopoietic cytokines. Much of the evidence implicating Stats in these cellular processes comes from studies of mutant cytokine receptors selectively uncoupled from Stat activation, dominant-inhibitory Stat mutants, and mice with targeted disruptions of Stat genes. Together these approaches provide strong evidence that Stat activation, particularly of Stat3 and Stat5, plays an important role in myeloid differentiation and survival.

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Abbreviations

CNTF:

ciliary neurotrophic factor

CT-1:

cardiotrophin-1

EGF:

epidermal growth factor

Epo:

erythropoietin

GM-CSF:

granulocyte-macrophage colony-stimulating factor

G-CSF:

granulocyte colony-stimulating factor

IL:

interleukin

LIF:

leukemia inhibitory factor

OSM:

oncostatin-M

Tpo:

thrombopoietin

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Acknowledgements

The authors acknowledge generous grant support from the National Institutes of Health and the American Cancer Society.

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Authors and Affiliations

  1. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 Biomedical Science Tower, Pittsburgh, 15261, Pennsylvania, PA, USA

    Thomas E Smithgall, Scott D Briggs, Steven Schreiner, Edwina C Lerner, Haiyun Cheng & Matthew B Wilson

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  1. Thomas E Smithgall
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  2. Scott D Briggs
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Smithgall, T., Briggs, S., Schreiner, S. et al. Control of myeloid differentiation and survival by Stats. Oncogene 19, 2612–2618 (2000). https://doi.org/10.1038/sj.onc.1203477

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