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  • Original Paper
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PDCD2 is a negative regulator of HCF-1 (C1)

Oncogene volume 21, pages 5245–5254 (2002)Cite this article

Abstract

Temperature sensitive mutations in host cell factor 1 (HCF-1) arrest cells in the middle of the G1 phase of the cycle. We have shown that the highly conserved C-terminal WYF domain of HCF-1 protein interacts with the MYND domain of the PDCD2 protein. This inter‐action is conserved between human HCF-1 and HCF-2 and the C. elegansHCF. Overexpression of PDCD2, which interacts with the N-CoR/mSin3A corepressor complexes, suppresses cotransfected HCF-1 complement‐ation of a temperature lesion in the endogenous HCF-1 protein. Overexpression of domains of either PDCD2 or HCF-1, which should interfere with interactions between these two proteins, enhances the complementation.

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Authors and Affiliations

  1. Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139-4307, Massachusetts, MA, USA

    Rebecca B Scarr & Phillip A Sharp

  2. The McGovern Institute for Brain Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139-4307, Massachusetts, MA, USA

    Rebecca B Scarr & Phillip A Sharp

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  1. Rebecca B Scarr
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Correspondence to Phillip A Sharp.

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Scarr, R., Sharp, P. PDCD2 is a negative regulator of HCF-1 (C1). Oncogene 21, 5245–5254 (2002). https://doi.org/10.1038/sj.onc.1205647

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