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Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

Oncogene volume 22, pages 7524–7536 (2003)Cite this article

Abstract

The clinical efficacy of anticancer nucleoside drugs depends on a complex interplay of transporters mediating entry of nucleoside drugs into cells, efflux mechanisms that remove drugs from intracellular compartments and cellular metabolism to active metabolites. Nucleoside transporters (NTs) are important determinants for salvage of preformed nucleosides and mediated uptake of antimetabolite nucleoside drugs into target cells. The focus of this review is the two families of human nucleoside transporters (hENTs, hCNTs) and their role in transport of cytotoxic chemotherapeutic nucleoside drugs. Resistance to anticancer nucleoside drugs is a major clinical problem in which NTs have been implicated. Single nucleotide polymorphisms (SNPs) in drug transporters may contribute to interindividual variation in response to nucleoside drugs. In this review, we give an overview of the functional and molecular characteristics of human NTs and their potential role in resistance to nucleoside drugs and discuss the potential use of genetic polymorphism analyses for NTs to address drug resistance.

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  1. James D Young: JDY is a Heritage Scientist of the Alberta Heritage Foundation for Medical Research

  2. Carol E Cass: CEC holds the Canada Research Chair in Oncology

Authors and Affiliations

  1. Membrane Protein Research Group, University of Alberta, Canada

    Vijaya L Damaraju, James D Young & Carol E Cass

  2. Department of Oncology, University of Alberta, Canada

    Vijaya L Damaraju, Sambasivarao Damaraju, John Mackey, Michael B Sawyer & Carol E Cass

  3. Department of Physiology, University of Alberta, Canada

    James D Young

  4. Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada

    Vijaya L Damaraju, Sambasivarao Damaraju, John Mackey, Michael B Sawyer & Carol E Cass

  5. School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK

    Stephen A Baldwin

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Damaraju, V., Damaraju, S., Young, J. et al. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22, 7524–7536 (2003). https://doi.org/10.1038/sj.onc.1206952

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  • DOI: https://doi.org/10.1038/sj.onc.1206952

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