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Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma

Oncogene volume 24, pages 7022–7030 (2005)Cite this article

Abstract

The mechanisms that regulate induction of the antiapoptotic state and mitogenic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we found that curcumin (diferuloylmethane), a natural compound isolated from the plant Curcuma Ionga, inhibits cell proliferation and induces apoptosis in a dose dependent manner in several PEL cell lines. Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1). Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5′-diphosphate-ribose polymerase (PARP) cleavage. Altogether, our findings suggest a novel function for curcumin, acting as a suppressor of JAK-1 and STAT3 activation in PEL cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis. Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3.

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Authors and Affiliations

  1. King Fahad National Center for Children's Cancer and Research, Riyadh, Saudi Arabia

    Shahab Uddin, Azhar R Hussain, Marina I Gutierrez & Kishor G Bhatia

  2. BMR, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    Pulicat S Manogaran & Khaled Al-Hussein

  3. Division of Hematology-Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL, USA

    Leonidas C Platanias

  4. Cancer Diagnosis Program, National Cancer Institute, Rockville, MD, USA

    Kishor G Bhatia

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  1. Shahab Uddin
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  2. Azhar R Hussain
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  3. Pulicat S Manogaran
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  4. Khaled Al-Hussein
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  5. Leonidas C Platanias
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  6. Marina I Gutierrez
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Correspondence to Shahab Uddin or Kishor G Bhatia.

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Uddin, S., Hussain, A., Manogaran, P. et al. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene 24, 7022–7030 (2005). https://doi.org/10.1038/sj.onc.1208864

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