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Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells

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Abstract

Of the thousands of proven carcinogens and toxic agents contained within a cigarette, nicotine, while being the addictive agent, is often viewed as the least harmful of these compounds. Nicotine is a lipophilic molecule whose effects on neuronal nicotinic acetylcholine receptors (nAChR) have been primarily focused on its physiologic impact within the confines of the brain and peripheral nervous system. However, recently, many studies have found neuronal nAChRs to be expressed on many different nonneuronal cell types throughout the body, where increasing evidence suggests they have important roles in determining the consequences of nicotine use on multiple organs systems and diseases as diverse as ulcerative colitis, chronic pulmonary obstructive disease, and diabetes, as well as the neurologic disorders of Parkinson’s and Alzheimer’s disease. This review highlights current evidence for the expression of peripheral nAChRs in cells other than neurons and how they participate in fundamental processes, such as inflammation. Understanding these processes may offer novel therapeutic strategies to approach inflammatory diseases, as well as precautions in the design of interventional drugs.

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Authors and Affiliations

  1. Geriatric Research Education and Clinical Center, Salt Lake City VAMC, 84132, Salt Lake City, Utah

    Lorise C. Gahring & Scott W. Rogers

  2. The Department of Neurobiology and Anatomy, University of Utah School of Medicine, 84132, Salt Lake City, Utah

    Scott W. Rogers

  3. Division of Geriatrics, SOM 2C110, Department of Internal Medicine, University of Utah School of Medicine, 50 North Medical Drive, 84132, Salt Lake City, UT

    Lorise C. Gahring

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  1. Lorise C. Gahring
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Correspondence to Lorise C. Gahring.

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Published: January 13, 2006

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Gahring, L.C., Rogers, S.W. Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. AAPS J 7, 86 (2005). https://doi.org/10.1208/aapsj070486

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