Skip to main content
SpringerLink
Log in

Interleukin-13

A key mediator in resistance to gastrointestinal-dwelling nematode parasites

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

Abstract

Gastrointestinal nematode parasites are one of the most prevalent types of infection worldwide. Evidence from both laboratory and human systems indicates that when resistance is evident immunity is mediated by effector mechanisms controlled by Thelper 2 type responses. Moreover, more recent evidence implicates a central role for interleukin 13. We raise the possibility that gut dwelling nematodes may have been an important driving force in the development of Th 2 responses involving IL-13. Moreover, that these parasites have evolved a variety of strategies to avoid destruction and to regulate any potential pathology associated with chronic infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Grencis, R.K. and Cooper, E.S. (1996), Gastroenterol. Clin. North Am. 25, 579–597.

    Article  PubMed  CAS  Google Scholar 

  2. Newton, S.E. and Munn, E.A. (1999), Parasitol. Today 15, 116–122.

    Article  PubMed  CAS  Google Scholar 

  3. Bundy, D.A.P. (1995), in Enteric Infection, 2nd ed., Farthing, M.J.G., Keusch, G.T., and Wakelin, D., eds., Chapman & Hall, London, 5–24.

    Google Scholar 

  4. Chan, M.S. (1997), Parasitol. Today 13, 438–443.

    Article  PubMed  CAS  Google Scholar 

  5. Albonico, M., Crompton, D.W.T., and Savioli, L. (1999), Adv. Parasitol. 42, 277–341.

    Article  PubMed  CAS  Google Scholar 

  6. Wills-Karp, M., Santeliz, J., and Karp, C.L. (2001), Nat. Rev. Immunol. 1, 69–75.

    Article  PubMed  CAS  Google Scholar 

  7. Yazdanbakhsh, M., Kremsner, P.G., and van Ree, R. (2002), Science 296, 490–494.

    Article  PubMed  CAS  Google Scholar 

  8. Brown, K.D., Zurawski, S.M., Mosmann, T.R., and Zurawski, G. (1989), J. Immunol. 142, 679–687.

    PubMed  CAS  Google Scholar 

  9. Minty, A., Chalon, P., Derocq, J.-M., et al. (1993), Nature 362, 248–250.

    Article  PubMed  CAS  Google Scholar 

  10. McKenzie, A.N., Culpepper, J.A., de Waal Malefyt, R., et al. (1993), Proc. Natl. Acad. Sci. USA 90, 3735–3739.

    Article  PubMed  CAS  Google Scholar 

  11. Whittaker, L., Niu, N., Temann, U.A., et al. (2002), Am. J. Respir. Cell Mol. Biol. 27, 593–602.

    PubMed  CAS  Google Scholar 

  12. Zurawski, G. and de Vries, J.E. (1994), Immunol. Today, 15, 19–26.

    Article  PubMed  CAS  Google Scholar 

  13. Wills-Karp, M. (2001), J. Allergy Clin. Immunol. 107, 9–18.

    Article  PubMed  CAS  Google Scholar 

  14. De Saint-Vis B, Fugier-Vivier, I., Massacrier, C., et al. (1998), J. Immunol. 60, 1666–1676.

    Google Scholar 

  15. Hoshino, T., Winkler, R.T., Mason, A.T., et al. (1999), J. Immunol. 162, 51–59.

    PubMed  CAS  Google Scholar 

  16. McKenzie, A.N.J., and Heath, A.W. (1996), Blood Cell Biochemistry: Hematopoietic Cell Growth Factors and Their Receptors. Plenum Press, New York, pp. 41–50.

    Google Scholar 

  17. Mosmann, T.R. and Coffman, R.L. (1989), Ann. Rev. Immunol. 7, 145–173.

    Article  CAS  Google Scholar 

  18. Mohrs, M., Ledermann, B., Köhler, G., et al. (1999), J. Immunol. 162, 7302–7308.

    PubMed  CAS  Google Scholar 

  19. Hilton, D.J., Zhang, J.G., Metcalf, D., et al. (1996), Proc. Natl. Acad. Sci. USA 93, 497–501.

    Article  PubMed  CAS  Google Scholar 

  20. Aman, M.J., Tayebi, N., Obiri, N.I., et al. (1996), J. Biol. Chem. 271, 29,265–29,270.

    CAS  Google Scholar 

  21. McKenzie, A.N.J. and Fallon, P.G. (2003), J. Exp. Med. 197, 675–679.

    Article  PubMed  CAS  Google Scholar 

  22. Chiaramonte, M.G., Mentink-Kane, M., Jacobson, B.A., et al. (2003), J. Exp. Med. 197, 687–701.

    Article  PubMed  CAS  Google Scholar 

  23. Wood, N., Whitters, M.J., Jacobson, B.A., et al. (2003), J. Exp. Med. 197, 703–709.

    Article  PubMed  CAS  Google Scholar 

  24. Takeda, K., Kamanaka, M., Tanaka, T., et al. (1996), J. Immunol. 157, 3220–3222.

    PubMed  CAS  Google Scholar 

  25. Kaplan, M.H., Schindler, U., Smiley, S.T., and Grusby, M.J. (1996), Immunity 4, 313–319.

    Article  PubMed  CAS  Google Scholar 

  26. Punnonen, J., Aversa, G., Cocks, B.G., et al. (1993), Proc. Natl. Acad. Sci. USA 90, 3730–3734.

    Article  PubMed  CAS  Google Scholar 

  27. Emson, C.L., Bell, S.E., Jones, A., et al. (1998), J. Exp. Med. 188, 399–404.

    Article  PubMed  CAS  Google Scholar 

  28. Brombacher, F. (2000), Bioessays 2000 22, 646–656.

    Article  CAS  Google Scholar 

  29. Lai, Y.H. and Mosmann, T.R. (1999), J. Immunol. 162, 78–87.

    PubMed  CAS  Google Scholar 

  30. Rutschman, R., Lang, R., Hesse, M., et al. (2001), J. Immunol. 166, 2173–2177.

    PubMed  CAS  Google Scholar 

  31. Abbas, A.K., Murphy, K.M., and Sher, A. (1996), Nature 383, 787–793.

    Article  PubMed  CAS  Google Scholar 

  32. Pritchard, D.I., Quinnell, R.J., and Walsh, E.A., (1995), Parasite Immunol. 17, 71–75.

    PubMed  CAS  Google Scholar 

  33. Pritchard, D.I., Quinnell, R.J., Slater, A.F.G., et al. (1990), Parasitology 100, 317–326.

    PubMed  Google Scholar 

  34. Pritchard, D.I., Hewitt, C., and Moqbel, R. (1997), Parasitology S33–S44.

  35. Prowse, S.J., Mitchell, G.F., Ey, P.L., and Jenkin, C.R. (1978), Aus. J. Exp. Biol. Med. Sci. 56, 561–570.

    CAS  Google Scholar 

  36. Vos, J.G., Ruitenberg, E.J., Van Basten, N., et al. (1983), Parasite Immunol. 5, 195–215.

    PubMed  CAS  Google Scholar 

  37. Else, K.J. and Grencis, R.K. (1996), Infect. Immun. 64, 2950–2954.

    PubMed  CAS  Google Scholar 

  38. Grencis, R.K., Reidlinger, J., and Wakelin, D. (1985), Immunology 56, 213–218.

    PubMed  CAS  Google Scholar 

  39. Katona, I.M., Urban, J.F., and Finkelman, F.D. (1988), J. Immunol. 140 3206–3211.

    PubMed  CAS  Google Scholar 

  40. Koyama, K., Tamanchi, H., and Ito, Y. (1995), Parasite Immunol. 17, 161–165.

    PubMed  CAS  Google Scholar 

  41. Urban, J.F., Katona, I.M., and Finkelman, F.D. (1991), Exp. Para. 73, 500–511.

    Article  CAS  Google Scholar 

  42. Mosmann, T.R., Cherwinski, H., Bond, M.W., et al. (1986), J. Immunol. 136, 2348–2357.

    PubMed  CAS  Google Scholar 

  43. Finkelman, F.D., Shea-Donohue, T., Goldhill, J., et al. (1997), Ann. Rev. Immunol. 15, 505–533.

    Article  CAS  Google Scholar 

  44. Donaldson, L.E., Schmitt, E., Huntey, J.F., et al. (1996), Intl. Immunol. 8, 559–567.

    Article  CAS  Google Scholar 

  45. Faulkner, H.F., Humphreys, N.H., Renauld, J.C., et al. (1997), Eur. J. Immunol. 27, 2536–2540.

    Article  PubMed  CAS  Google Scholar 

  46. Knight, P.A., Wright, S.H., Lawrence, C.E., et al. (2000), J. Exp. Med. 192, 1849–1856.

    Article  PubMed  CAS  Google Scholar 

  47. McDermott, J.R., Bartram, R.E., Knight, P.A., et al. Proc. Natl. Acad. Sci. USA, 100, 7761–7766.

  48. Kennedy, M.W., Wakelin, D., and Wilson, M.M. (1979), Parasitology, 78, 121–130.

    Article  PubMed  CAS  Google Scholar 

  49. Grencis, R.K. (1997), Phil. Trans. R. Soc. Lond. B. 352, 1377–1384.

    Article  CAS  Google Scholar 

  50. Wahid, F.N., Behnke, J.M., Grencis, R.K., et al. (1994), Parasitology 108, 461–471.

    Article  PubMed  CAS  Google Scholar 

  51. Crowle, P.K. and Reed, N.D. (1981), Infect. Immun. 33, 54–58.

    PubMed  CAS  Google Scholar 

  52. Betts, C.J. and Else, K.J. (1999), Parasite Immunol. 21, 45–52.

    Article  PubMed  CAS  Google Scholar 

  53. Coffman, R.L., Seymour, B.W.P., Hudak, S., et al. (1989), Science 245, 308–310.

    Article  PubMed  CAS  Google Scholar 

  54. Dent, L.A., Daly, C.M., Mayrhofer, G., et al. (1999), Infect. Immun. 67, 989–993.

    PubMed  CAS  Google Scholar 

  55. Khan, W.I., Abe, T., Ishikawa, N., et al. (1995), Parasite Immunol. 17 485–491.

    PubMed  CAS  Google Scholar 

  56. Turner, J., Faulkner, H., Kamgno, J., et al. (2002), Parasite Immunol. 24, 83–93.

    Article  PubMed  CAS  Google Scholar 

  57. Faulkner, H., Turner, J., Kamgno, J., et al. (2003), J. Infect. Dis. 185, 665–672.

    Article  Google Scholar 

  58. Cooper, P.J., Chico, M.E., Sandoval, C., et al. (2000), J. Infect. Dis. 182 1207–1213.

    Article  PubMed  CAS  Google Scholar 

  59. Turner, J., Faulkner, H., Kamngo, J., et al. J. Infect. Dis. 188, 1768–1775.

  60. Grencis, R.K. (2003), in Interleukin-13, Brombacher, F., ed. Landes Bioscience, USA, pp. 51–61.

    Google Scholar 

  61. Lawrence, R.A., Gray, C.A., Osbourne, J., and Maizels, R. (1996), Exp. Para. 84, 65–73.

    Article  CAS  Google Scholar 

  62. McKenzie, G.J., Bancroft, A.J., Grencis, R.K., and McKenzie, A.N.J. (1998), Curr. Biol. 8, 339–342.

    Article  PubMed  CAS  Google Scholar 

  63. Noben-Trauth, N., Shultz, L.D., Brombacher, F., et al. (1997), Proc. Natl. Acad. Sci. USA 94, 10,838–10,843.

    Article  CAS  Google Scholar 

  64. Urban, J.F., Noben-Trauth, N., Donaldson, D.D., et al. (1998), Immunity, 8, 255–264.

    Article  PubMed  CAS  Google Scholar 

  65. Barner, M., Mohrs, M., Brombacher, F., and Kopf, M. (1998), Curr. Biol. 8 669–672.

    Article  PubMed  CAS  Google Scholar 

  66. Urban, J.F., Noben-Trauth, N., Schopf, L., et al. (2001), J. Immunol. 167, 6078–6081.

    PubMed  CAS  Google Scholar 

  67. Bundy, D.A.P. (1997), Parasitol. Today, 13, 407–408.

    Article  Google Scholar 

  68. Else, K.J. and Grencis, R.K. (1991), Immunology 72, 508–513.

    PubMed  CAS  Google Scholar 

  69. Else, K.J., Hüntner, L., and Grencis, R.K. (1992) Immunology 75, 232–237.

    PubMed  CAS  Google Scholar 

  70. Else, K.J., Finkelman, F.D., Maliszewski, C.R., and Gencis, R.K. (1994), J. Exp. Med. 179, 347–351.

    Article  PubMed  CAS  Google Scholar 

  71. Bancroft, A.J., McKenzie, A.N.J., and Grencis, R.K. (1998), J. Immunol. 160, 3453–3461.

    PubMed  CAS  Google Scholar 

  72. Bancroft, A.J., Artis, D., Donaldson, D.D. et al. (2000), Eur J. Immunol. 30, 2083–2091.

    Article  PubMed  CAS  Google Scholar 

  73. Artis, D., Humphreys, N.E., Bancroft, A.J., et al. (1999), J. Exp. Med. 190, 953–962.

    Article  PubMed  CAS  Google Scholar 

  74. Artis, D., Potten, C.S., Else, K.J., et al. (1999), Exp. Para. 92, 144–153.

    Article  CAS  Google Scholar 

  75. Garside, P., Grencis, R.K., and McI Mowat, A.M. (1992), Parasite Immunol. 14, 217–225.

    PubMed  CAS  Google Scholar 

  76. Khan, W.I., Vallance, B.A., Blenerhasset, P.A., et al. (2001), Infect. Immun. 69, 838–844.

    Article  PubMed  CAS  Google Scholar 

  77. Behnke, J.M., Barnard, C.J., and Wakelin, D. (1992), Int. J. Parasitol. 22, 861–907.

    Article  PubMed  CAS  Google Scholar 

  78. Behnke, J.M., Wahid, F.N., Grencis, R.K., et al. (1993), Parasite Immunol. 15, 415–421.

    PubMed  CAS  Google Scholar 

  79. Finkelman, F.D., Morris, S.C., Orekhova, T., et al. (2000), J. Immunol. 164, 2303–2310.

    PubMed  CAS  Google Scholar 

  80. Duschl, A. (2003), in Interleukin-13, Brombacher, F., ed., Landes Bioscience, USA, pp. 79–87.

    Google Scholar 

  81. Naseer, T., Minshull, E.M., and Leung, D.Y. (1997), Am. J. Respir. Crit. Care Med. 155, 845–851.

    PubMed  CAS  Google Scholar 

  82. Grünig, G., Warnock, M., Wakil, A.E, et al. (1998), Science 282, 2261–2263.

    Article  PubMed  Google Scholar 

  83. Wills-Karp, M., Luyimbazi, J., Xu, X., et al. (1998), Science 282, 2258–2261.

    Article  PubMed  CAS  Google Scholar 

  84. Venkayya, R., Lam, M., Willkom, M., et al. (2002), Am. J. Respir. Cell Mol. Biol. 26, 202–208.

    PubMed  CAS  Google Scholar 

  85. Kuperman, D.A., Huang, X., Koth, L.L., et al. (2002), Nature Med. 8, 885–889.

    PubMed  CAS  Google Scholar 

  86. Lee, J.H., Kaminski, N., Dolganov, G., et al. (2001), Am. J. Respir. Cell Mol. Biol. 25, 474–485.

    PubMed  CAS  Google Scholar 

  87. Bancroft, A.J., Else, K.J., and Grencis, R.K. (1994), Eur. J. Immunol. 24, 3113–3118.

    Article  PubMed  CAS  Google Scholar 

  88. Bancroft, A.J., Else, K.J., Sypek, J.P., and Grencis, R.K. (1997), Eur. J. Immunol. 27, 866–870.

    Article  PubMed  CAS  Google Scholar 

  89. Bancroft, A.J., Else, K.J., Humphreys, N.E., and Grencis, R.K. (2001), Int. J. Parasitol. 31,1627–1637.

    Article  PubMed  CAS  Google Scholar 

  90. Bashir, M.E.H., Andersen, P., Fuss, I.J., et al. (2002), J. Immunol. 169, 3284–3292.

    PubMed  CAS  Google Scholar 

  91. Schopf, L.R., Hoffman, K.F., Cheever, A.W., et al. (2002), J. Immunol. 168, 2383–2392.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, Oxford Road, M13 9PT, Manchester, UK

    Richard K. Grencis & Allison J. Bancroft

Authors
  1. Richard K. Grencis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Allison J. Bancroft
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard K. Grencis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grencis, R.K., Bancroft, A.J. Interleukin-13. Clinic Rev Allerg Immunol 26, 51–60 (2004). https://doi.org/10.1385/CRIAI:26:1:51

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/CRIAI:26:1:51

Index Entries

Search

Navigation