ReviewThe Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism
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Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures
2024, Toxicology in VitroAssessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
2023, Regulatory Toxicology and PharmacologyConstitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation
2021, Acta Pharmaceutica Sinica BCitation Excerpt :The constitutive androstane receptor (CAR, NR3I1), is a xenobiotic-sensing nuclear receptor, and a member of the nuclear receptor superfamily1.
PXR is a target of (-)-epicatechin in skeletal muscle
2020, HeliyonCitation Excerpt :We discard estrogen receptors (ERα), since it has been proved that the effects of EC in endothelial cells cannot be blocked with selective antagonist (i.e. tamoxifen) [10] and GPER, whose effects on endothelial cells have already been described [8]. By this and considering the reported effects attributed to the stimuli of this receptor in different tissues [11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21], the most feasible option was pregnane X receptor (PXR). To confirm the hypothesis that PXR specifically interacts with EC, in silico analysis of the affinity characteristics between EC, PCN and the LBD of mPXR was performed.
Clinical applications of small molecule inhibitors of Pregnane X receptor
2019, Molecular and Cellular Endocrinology