The Japanese Journal of Physiology
Print ISSN : 0021-521X
Regular Papers
Effects of Moderate Altitude on Exhaled Nitric Oxide, Erythrocytes Lipid Peroxidation and Superoxide Dismutase Levels
Nevin Atalay GüzelHale SayanDeniz Erabas
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2000 Volume 50 Issue 2 Pages 187-190

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Abstract

The purpose of this study was to investigate the effects of staying at a moderate altitude (2,300 m, 7 d) on the levels of plasma nitrite, exhaled nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD). Measurements were obtained from 9 female (mean age 18.3 ± 2) and 9 male (mean age 19.3 ± 3.7) cross-country volunteer skiers: before, during (1st day, 7th day) and after staying at a moderate altitude. Exhaled nitric oxide levels were measured only before and after staying at the altitude. Nitrite levels increased throughout the stay at the altitude, while MDA levels decreased. In parallel with the nitrite levels, SOD activities were also found to have increased. Exhaled NO values were decreased after the stay at the moderate altitude. These results show that altitude hypoxia causes decreased in NO levels in the lung but increased systemic NO levels in the blood due to inhibition of erythrocyte lipid peroxidation.

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© 2000 by The Physiological Society of Japan
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