Abstract
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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AMP-Activated Protein Kinases
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Cholesterol / biosynthesis
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Creatine Kinase / metabolism
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Energy Metabolism
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Fatty Acids / metabolism
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Glucose / metabolism
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Isoenzymes / chemistry
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Isoenzymes / metabolism
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Multienzyme Complexes / chemistry
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Multienzyme Complexes / metabolism*
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Protein Conformation
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Protein Kinases / chemistry
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / metabolism
Substances
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Fatty Acids
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Isoenzymes
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Multienzyme Complexes
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Cholesterol
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Protein Kinases
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SNF1-related protein kinases
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Creatine Kinase
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Glucose