Abstract
Plasma agmatine concentrations are elevated significantly in depressed patients compared to healthy controls. Treatment with the antidepressant bupropion normalized plasma agmatine levels. Correlational evidence is presented that a change in plasma agmatine levels may lead to similar changes in platelet I1 imidazoline receptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Agmatine / blood*
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Antidepressive Agents, Second-Generation / therapeutic use
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Blood Platelets / metabolism*
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Bupropion / therapeutic use
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Cohort Studies
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Depressive Disorder / blood*
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Depressive Disorder / drug therapy
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Humans
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Imidazoles / pharmacokinetics
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Imidazoline Receptors
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Multivariate Analysis
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Receptors, Drug / blood*
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Reference Values
Substances
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Antidepressive Agents, Second-Generation
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Imidazoles
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Imidazoline Receptors
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Receptors, Drug
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Bupropion
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Agmatine