Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities

J Med Chem. 1999 Aug 12;42(16):3018-22. doi: 10.1021/jm9902279.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Camptothecin / analogs & derivatives*
  • Camptothecin / blood
  • Camptothecin / chemical synthesis*
  • Camptothecin / chemistry
  • Chromatography, High Pressure Liquid
  • Dimyristoylphosphatidylcholine / chemistry
  • Drug Stability
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fluorescence Polarization
  • Humans
  • Hydrolysis
  • Phosphatidylglycerols / chemistry
  • Spectrometry, Fluorescence
  • Structure-Activity Relationship
  • Topoisomerase I Inhibitors*

Substances

  • Enzyme Inhibitors
  • Phosphatidylglycerols
  • Topoisomerase I Inhibitors
  • dimyristoylphosphatidylglycerol
  • Dimyristoylphosphatidylcholine
  • Camptothecin