Newly developed in silico protein design methods have recently been applied to problems in protein stabilization. Stabilized protein sequences can be designed by combining potential functions that model a protein sequence's compatibility with a structure and fast optimization tools that can search the enormous number of sequence possibilities. The experimental testing of several sequence-design strategies has demonstrated that a wide range of protein structures can be stabilized. The primary advantage of in silico design is the vast number of sequences that can be rapidly screened in the search for an optimal design, far exceeding non-computational methods. This feature allows very large changes in protein properties to be discovered.