A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity

J Med Chem. 1999 Sep 23;42(19):3785-8. doi: 10.1021/jm9903601.
No abstract available

MeSH terms

  • Animals
  • Butyrates / pharmacology*
  • DNA-Binding Proteins / agonists*
  • Fenofibrate / pharmacology
  • Humans
  • Hypolipidemic Agents / pharmacology*
  • Lipid Metabolism*
  • Male
  • Mice
  • Nuclear Proteins / agonists*
  • Phenylurea Compounds / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Transcription Factors / agonists*
  • Zinc Fingers*

Substances

  • Butyrates
  • DNA-Binding Proteins
  • Hypolipidemic Agents
  • Nuclear Proteins
  • Phenylurea Compounds
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • GW 9578
  • Fenofibrate