Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

J S Zhang; J Ding; Q M Tang; M Li; M Zhao; L J Lu; L J Chen; S T Yuan

doi:10.1016/s0960-894x(99)00472-2

Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2731-6. doi: 10.1016/s0960-894x(99)00472-2.

Authors

J S Zhang¹, J Ding, Q M Tang, M Li, M Zhao, L J Lu, L J Chen, S T Yuan

Affiliation

¹ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. jszhang@mail.shcnc.ac.cn

PMID: 10509925
DOI: 10.1016/s0960-894x(99)00472-2

Abstract

A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Naphthoquinones / chemical synthesis*
Naphthoquinones / chemistry
Naphthoquinones / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Naphthoquinones
salvicine