Abstract
The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / pharmacology
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Humans
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Indicators and Reagents
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Isoenzymes / antagonists & inhibitors
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Lysine / analogs & derivatives*
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Lysine / chemical synthesis*
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Lysine / pharmacology
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type II
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Ornithine / analogs & derivatives
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Ornithine / pharmacology
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Sulfides / pharmacology
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Sulfones / pharmacology
Substances
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Acetamides
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Enzyme Inhibitors
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GW 273629
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Indicators and Reagents
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Isoenzymes
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Sulfides
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Sulfones
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GW 274150
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Ornithine
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Lysine