How to activate p53

Curr Biol. 2000 Apr 20;10(8):R315-7. doi: 10.1016/s0960-9822(00)00439-5.

Abstract

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

Publication types

  • Review

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Binding Sites
  • Cell Cycle Proteins / metabolism*
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage
  • DNA-Binding Proteins
  • Humans
  • Nuclear Proteins*
  • Phosphorylation / radiation effects
  • Protein Kinases / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-mdm2
  • Tumor Suppressor Protein p53 / metabolism*
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human
  • Checkpoint Kinase 1
  • Protein Serine-Threonine Kinases