The newer macrolides: azithromycin and clarithromycin

Infect Dis Clin North Am. 2000 Jun;14(2):449-62, x. doi: 10.1016/s0891-5520(05)70257-9.

Abstract

Azithromycin and clarithromycin are two relatively new macrolide antimicrobial agents. Although azithromycin and clarithromycin are structural analogues of erythromycin, they offer distinct advantages in comparison. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse affects of these antimicrobial agents.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / adverse effects
  • Azithromycin / chemistry
  • Azithromycin / pharmacokinetics
  • Azithromycin / therapeutic use*
  • Bacterial Infections / drug therapy*
  • Clarithromycin / adverse effects
  • Clarithromycin / chemistry
  • Clarithromycin / pharmacokinetics
  • Clarithromycin / therapeutic use*
  • Drug Resistance, Microbial
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans

Substances

  • Anti-Bacterial Agents
  • Azithromycin
  • Clarithromycin