2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice

Eur J Pharmacol. 2000 Oct 6;406(1):R5-7. doi: 10.1016/s0014-2999(00)00653-1.

Abstract

2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arachidonic Acids*
  • Cannabinoids / pharmacology
  • Cell Line
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Endocannabinoids
  • Glycerides / pharmacology*
  • Macrophages, Peritoneal / cytology
  • Macrophages, Peritoneal / drug effects*
  • Macrophages, Peritoneal / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Tumor Necrosis Factor-alpha / biosynthesis*

Substances

  • Arachidonic Acids
  • Cannabinoids
  • Endocannabinoids
  • Glycerides
  • Tumor Necrosis Factor-alpha
  • 2-palmitoylglycerol
  • 2-linoleoylglycerol
  • glyceryl 2-arachidonate