Abstract
2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arachidonic Acids*
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Cannabinoids / pharmacology
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Cell Line
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Dose-Response Relationship, Drug
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Drug Synergism
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Endocannabinoids
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Glycerides / pharmacology*
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Macrophages, Peritoneal / cytology
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Macrophages, Peritoneal / drug effects*
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Macrophages, Peritoneal / metabolism
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Arachidonic Acids
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Cannabinoids
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Endocannabinoids
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Glycerides
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Tumor Necrosis Factor-alpha
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2-palmitoylglycerol
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2-linoleoylglycerol
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glyceryl 2-arachidonate