Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain

R Rimini; J M Rimland; G C Terstappen

doi:10.1016/s0169-328x(00)00255-2

Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain

Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):218-20. doi: 10.1016/s0169-328x(00)00255-2.

Authors

R Rimini¹, J M Rimland, G C Terstappen

Affiliation

¹ Molecular Biology and Biochemistry Unit, Biology Department, GlaxoWellcome Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy.

PMID: 11146124
DOI: 10.1016/s0169-328x(00)00255-2

Abstract

Small conductance calcium-activated potassium (SK) channels are important in controlling neuronal excitability and three SK channels have been identified to date. In the present study, we report the first quantitative analysis of SK1, SK2 and SK3 expression in human brain using TaqMan RT-PCR on a range of human brain and peripheral tissue samples. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed.

MeSH terms

Brain Chemistry / genetics*
Gene Expression / physiology
Humans
Potassium Channels / genetics*
Potassium Channels, Calcium-Activated*
Reverse Transcriptase Polymerase Chain Reaction*
Small-Conductance Calcium-Activated Potassium Channels
Transcription, Genetic / physiology

Substances

KCNN1 protein, human
KCNN2 protein, human
Potassium Channels
Potassium Channels, Calcium-Activated
Small-Conductance Calcium-Activated Potassium Channels