Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain

S Srinivasan; C McGuigan; G Andrei; R Snoeck; E De Clercq; J Balzarini

doi:10.1016/s0960-894x(00)00672-7

Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain

Bioorg Med Chem Lett. 2001 Feb 12;11(3):391-3. doi: 10.1016/s0960-894x(00)00672-7.

Authors

S Srinivasan¹, C McGuigan, G Andrei, R Snoeck, E De Clercq, J Balzarini

Affiliation

¹ Welsh School of Pharmacy, Cardiff University, King Edward, Cardiff, UK.

PMID: 11212118
DOI: 10.1016/s0960-894x(00)00672-7

Abstract

Novel bicyclic nucleoside analogues bearing long alkyl side chains are prepared and tested as inhibitors of VZV. In particular, analogues with terminal unsaturation in the side chain are reported. Whilst terminal alkenyl derivatives are potent antivirals, the corresponding terminal alkynyls are poorly active.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Cell Line / cytology
Cell Line / drug effects
Cell Survival / drug effects
Combinatorial Chemistry Techniques
Herpesvirus 3, Human / drug effects*
Humans
Inhibitory Concentration 50
Microbial Sensitivity Tests
Nucleosides / chemical synthesis
Nucleosides / pharmacology*
Structure-Activity Relationship

Substances

Antiviral Agents
Bridged Bicyclo Compounds, Heterocyclic
Nucleosides