Filamins as integrators of cell mechanics and signalling

T P Stossel; J Condeelis; L Cooley; J H Hartwig; A Noegel; M Schleicher; S S Shapiro

doi:10.1038/35052082

Filamins as integrators of cell mechanics and signalling

Nat Rev Mol Cell Biol. 2001 Feb;2(2):138-45. doi: 10.1038/35052082.

Authors

T P Stossel¹, J Condeelis, L Cooley, J H Hartwig, A Noegel, M Schleicher, S S Shapiro

Affiliation

¹ Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. tstossel@rics.bwh.harvard.edu

PMID: 11252955
DOI: 10.1038/35052082

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Cell Membrane / physiology
Contractile Proteins / physiology*
Filamins
Microfilament Proteins / physiology*
Signal Transduction / physiology*

Substances

Contractile Proteins
Filamins
Microfilament Proteins