Metabolism of fluorine-containing drugs

B K Park; N R Kitteringham; P M O'Neill

doi:10.1146/annurev.pharmtox.41.1.443

Metabolism of fluorine-containing drugs

Annu Rev Pharmacol Toxicol. 2001:41:443-70. doi: 10.1146/annurev.pharmtox.41.1.443.

Authors

B K Park¹, N R Kitteringham, P M O'Neill

Affiliation

¹ Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom. bkpark@liverpool.ac.uk

PMID: 11264465
DOI: 10.1146/annurev.pharmtox.41.1.443

Abstract

This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Fluorine Compounds / chemistry
Fluorine Compounds / metabolism*
Fluorine Compounds / pharmacokinetics
Humans
Pharmaceutical Preparations / metabolism*
Tissue Distribution

Substances

Fluorine Compounds
Pharmaceutical Preparations