Molecular dissection of autophagy: two ubiquitin-like systems

Nat Rev Mol Cell Biol. 2001 Mar;2(3):211-6. doi: 10.1038/35056522.

Abstract

Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.

Publication types

  • Review

MeSH terms

  • Autophagy / physiology*
  • Autophagy-Related Protein 7
  • Autophagy-Related Protein 8 Family
  • Lysosomes / metabolism
  • Microscopy, Electron
  • Microtubule-Associated Proteins / metabolism
  • Models, Biological
  • Proteins / metabolism
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae / ultrastructure
  • Saccharomyces cerevisiae Proteins*
  • Ubiquitins / metabolism*
  • Vacuoles / metabolism

Substances

  • ATG7 protein, S cerevisiae
  • ATG8 protein, S cerevisiae
  • Autophagy-Related Protein 8 Family
  • Microtubule-Associated Proteins
  • Proteins
  • Saccharomyces cerevisiae Proteins
  • Ubiquitins
  • Autophagy-Related Protein 7