NO-independent stimulators of soluble guanylate cyclase

Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4. doi: 10.1016/s0960-894x(01)00073-7.

Abstract

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.

MeSH terms

  • Animals
  • Aorta / drug effects
  • Aorta / physiology
  • Enzyme Activators / chemical synthesis
  • Enzyme Activators / chemistry
  • Enzyme Activators / pharmacology*
  • Guanylate Cyclase / metabolism*
  • Indazoles / chemical synthesis
  • Indazoles / chemistry
  • Indazoles / pharmacology*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology
  • Pyridines / chemistry
  • Pyridines / pharmacology
  • Rabbits
  • Structure-Activity Relationship
  • Vasodilation / drug effects

Substances

  • 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
  • Enzyme Activators
  • Indazoles
  • Pyrazoles
  • Pyridines
  • 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
  • Guanylate Cyclase