Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors

C A Brady; I M Stanford; I Ali; L Lin; J M Williams; A E Dubin; A G Hope; N M Barnes

doi:10.1016/s0028-3908(01)00074-0

Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors

Neuropharmacology. 2001 Aug;41(2):282-4. doi: 10.1016/s0028-3908(01)00074-0.

Authors

C A Brady¹, I M Stanford, I Ali, L Lin, J M Williams, A E Dubin, A G Hope, N M Barnes

Affiliation

¹ Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

PMID: 11489465
DOI: 10.1016/s0028-3908(01)00074-0

Abstract

The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Free Radical Scavengers / pharmacology
Humans
Ion Channel Gating
Kidney / cytology
Kidney / drug effects
Kidney / metabolism
Receptors, Serotonin / biosynthesis*
Receptors, Serotonin / classification
Receptors, Serotonin, 5-HT3
Serotonin / pharmacology

Substances

Free Radical Scavengers
Receptors, Serotonin
Receptors, Serotonin, 5-HT3
Serotonin