Abstract
Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes, tumor suppressors, transcription factors, xenobiotic enzymes, metastatic proteins, differentiation markers, and genes that have not been implicated in oral cancer. The database created provides a verifiable global profile of gene expression during oral carcinogenesis, revealing the potential role of known genes as well as genes that have not been previously implicated in oral cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Cathepsin L
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Cathepsins / biosynthesis
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Collagenases / biosynthesis
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Cysteine Endopeptidases
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DNA, Complementary / metabolism
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Databases, Factual
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Down-Regulation
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Epithelial Cells / pathology
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Female
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Humans
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Male
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Middle Aged
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Models, Biological
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Mouth Mucosa / pathology
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Mouth Neoplasms / genetics*
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Mouth Neoplasms / metabolism
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Mouth Neoplasms / pathology
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Multigene Family
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Oligonucleotide Array Sequence Analysis*
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Reverse Transcriptase Polymerase Chain Reaction
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Software
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Up-Regulation
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Urokinase-Type Plasminogen Activator / biosynthesis
Substances
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DNA, Complementary
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Cathepsins
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Urokinase-Type Plasminogen Activator
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Cysteine Endopeptidases
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CTSL protein, human
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Cathepsin L
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Collagenases