First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants

Bioorg Med Chem Lett. 2002 Jan 21;12(2):261-4. doi: 10.1016/s0960-894x(01)00727-2.

Abstract

Compounds combining NK(1) antagonism and serotonin reuptake inhibition are described, and potentially represent a new generation of antidepressants. Compound 24 displays good affinities for both the NK(1) receptor and the serotonin reuptake site (32 and 25 nM, respectively).

MeSH terms

  • Antidepressive Agents / chemical synthesis
  • Antidepressive Agents / chemistry*
  • Antidepressive Agents / pharmacology*
  • Neurokinin-1 Receptor Antagonists*
  • Selective Serotonin Reuptake Inhibitors / chemical synthesis
  • Selective Serotonin Reuptake Inhibitors / chemistry
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antidepressive Agents
  • Neurokinin-1 Receptor Antagonists
  • Serotonin Uptake Inhibitors