The unfolding tale of the unfolded protein response

Cell. 2001 Dec 28;107(7):827-30. doi: 10.1016/s0092-8674(01)00623-7.

Abstract

Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Fungal Proteins / physiology
  • Humans
  • Membrane Glycoproteins / physiology
  • Protein Folding*
  • Protein Serine-Threonine Kinases*
  • Protein Transport* / physiology
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction

Substances

  • Fungal Proteins
  • Membrane Glycoproteins
  • Saccharomyces cerevisiae Proteins
  • IRE1 protein, S cerevisiae
  • Protein Serine-Threonine Kinases