Abstract
Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.
MeSH terms
-
Animals
-
Antigens, CD / physiology
-
Apoptosis / physiology*
-
Humans
-
Inhibitor of Apoptosis Proteins
-
Insect Proteins / physiology
-
Mitochondria / physiology
-
Models, Biological
-
Proteins*
-
Receptors, Tumor Necrosis Factor / physiology*
-
Receptors, Tumor Necrosis Factor, Type I
-
Receptors, Tumor Necrosis Factor, Type II
-
Signal Transduction
-
Tumor Necrosis Factor-alpha / physiology
Substances
-
Antigens, CD
-
Inhibitor of Apoptosis Proteins
-
Insect Proteins
-
Proteins
-
Receptors, Tumor Necrosis Factor
-
Receptors, Tumor Necrosis Factor, Type I
-
Receptors, Tumor Necrosis Factor, Type II
-
Tumor Necrosis Factor-alpha