Abstract
Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi-treated relapsing HPV-associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir.
Copyright 2002 Wiley-Liss, Inc.
MeSH terms
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Administration, Topical
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Adult
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Cidofovir
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Condylomata Acuminata / drug therapy*
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Condylomata Acuminata / virology
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Cytosine / administration & dosage
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Cytosine / analogs & derivatives
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Cytosine / therapeutic use*
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Female
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Humans
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Male
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Middle Aged
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Organophosphonates*
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Organophosphorus Compounds / administration & dosage
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Organophosphorus Compounds / therapeutic use*
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Papillomaviridae / drug effects
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Treatment Outcome
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Warts / drug therapy*
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Warts / virology
Substances
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Antiviral Agents
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Organophosphonates
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Organophosphorus Compounds
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Cytosine
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Cidofovir