Local treatment of HPV-induced skin lesions by Cidofovir

J Med Virol. 2002 Jun;67(2):241-5. doi: 10.1002/jmv.2213.

Abstract

Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi-treated relapsing HPV-associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Cidofovir
  • Condylomata Acuminata / drug therapy*
  • Condylomata Acuminata / virology
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives
  • Cytosine / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organophosphonates*
  • Organophosphorus Compounds / administration & dosage
  • Organophosphorus Compounds / therapeutic use*
  • Papillomaviridae / drug effects
  • Treatment Outcome
  • Warts / drug therapy*
  • Warts / virology

Substances

  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Cidofovir