Abstract
Cells in early stages of chromosome condensation are very vulnerable, and many stresses that do not damage DNA induce a transient return to late G2 phase. Such stresses include the drug-induced disassembly of microtubules, which triggers an ATM-independent G2 checkpoint pathway involving a novel ubiquitin ligase.
MeSH terms
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Cell Cycle / drug effects
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Cell Cycle / physiology*
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Cell Cycle Proteins / metabolism
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G2 Phase / drug effects
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G2 Phase / radiation effects
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Humans
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Microtubules / drug effects
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Microtubules / metabolism*
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Mitosis / drug effects
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Mitosis / physiology*
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Neoplasm Proteins*
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Nocodazole / pharmacology*
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Poly-ADP-Ribose Binding Proteins
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Ubiquitin-Protein Ligases
Substances
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Cell Cycle Proteins
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Neoplasm Proteins
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Poly-ADP-Ribose Binding Proteins
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CHFR protein, human
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Ubiquitin-Protein Ligases
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Nocodazole