Abstract
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism
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Brain Chemistry*
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Ligands / analysis*
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Muscle Contraction / drug effects
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Naloxone / pharmacology
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Nerve Tissue Proteins / analysis*
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Nerve Tissue Proteins / pharmacology
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Oligopeptides / analysis*
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Oligopeptides / pharmacology
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Opium / metabolism*
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Receptors, Drug*
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Swine
Substances
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Ligands
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Nerve Tissue Proteins
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Oligopeptides
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Receptors, Drug
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Naloxone
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Opium